From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveModerate evidence
What is happening. Sucralfate can bind iron in the gut and may reduce iron absorption or the absorption of other oral medications taken with iron.
Mechanism. Physical adsorption and complex formation in the gastrointestinal lumen.
Recommendation. Separate iron from sucralfate by at least 2 hours, and longer if response is inadequate.
TimingTiming & separation.
Space the doses apart by at least this window to avoid the conflict.
Stack Score
How it moves the number.
Effect on the composite score
If both Iron and Sucralfate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Sucralfate Tablets US Prescribing Information. 2026.Needs sourceNo link