NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Calcium and Sucralfate: what the published research says

PubMed indexes 5 records that name Calcium and Sucralfate together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Sucralfate. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

5 studies naming Calcium and Sucralfate.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Changes in serum phosphorus, calcium and alkaline phosphatase due to sucralfate.

International journal of clinical pharmacology, therapy, and toxicology · 1986 · PMID 3514490

Clinical Trial30 participants

“On the basis of its proven hypophosphatemic and ulcer-healing effects, sucralfate can be recommended in treatment of hyperphosphatemia and secondary hyperparathyroidism in chronic renal failure. Serum phosphorus should be checked routinely in patients treated with sucralfate for the peptic ulcer disease.”

Vucelić et al. · From the abstract

Names both Calcium and Sucralfate in its title.

Effect of sucralfate on gastric mucosal calcium channels activity.

General pharmacology · 1992 · PMID 1283137

Animal study

“4. The results indicate that sucralfate protects the cellular integrity from calcium imbalance by modulating the EGF-stimulated gastric mucosal calcium channel phosphorylation.”

Liu et al. · From the abstract

Names both Calcium and Sucralfate in its title.

Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).

The Cochrane database of systematic reviews · 2018 · PMID 30132304

Meta-AnalysisSystematic ReviewHuman subjects

“In studies of adults with CKD G5D treated with dialysis, sevelamer may lower death (all causes) compared to calcium-based binders and incur less treatment-related hypercalcaemia, while we found no clinically important benefits of any phosphate binder on cardiovascular death, myocardial infarction, stroke, fracture or coronary artery calcification. The effects of binders on patient-important outcomes compared to placebo are uncertain.”

Ruospo et al. · Authors' conclusion

Names Calcium and Sucralfate together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Sucralfate, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.