Supplement × Prescription·timing-sensitive·Emerging evidence

Sucralfate + Zinc

Timing Sensitive Emerging evidence

Sucralfate can physically bind oral minerals; zinc taken at the same time may have less predictable absorption.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Timing Sensitive
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveEmerging evidence

What is happening. Sucralfate can physically bind oral minerals; zinc taken at the same time may have less predictable absorption.

Mechanism. Adsorption and cation complexation in the gastrointestinal tract.

Recommendation. Separate zinc and sucralfate by at least 2 hours and reassess if zinc is being used for a documented deficiency.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation
120
Stack Score

How it moves the number.

Effect on the composite score

If both Sucralfate and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Sucralfate Tablets US Prescribing Information. 2026.Needs sourceNo link

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