From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveEmerging evidence
What is happening. Sucralfate can physically bind oral minerals; zinc taken at the same time may have less predictable absorption.
Mechanism. Adsorption and cation complexation in the gastrointestinal tract.
Recommendation. Separate zinc and sucralfate by at least 2 hours and reassess if zinc is being used for a documented deficiency.
TimingTiming & separation.
Space the doses apart by at least this window to avoid the conflict.
Stack Score
How it moves the number.
Effect on the composite score
If both Sucralfate and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Sucralfate Tablets US Prescribing Information. 2026.Needs sourceNo link