Manganese and Vitamin C: what the published research says
PubMed indexes 6 records that name Manganese and Vitamin C together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Manganese and Vitamin C. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.
The research
6 studies naming Manganese and Vitamin C.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
The American journal of clinical nutrition · 1995 · PMID 7572746
Clinical TrialRandomized Controlled Trial
“Manganese absorption was not influenced by an increase in the ascorbic acid from 625 mumol/L (110 mg/L) to 1250 mumol/L (220 mg/L): the geometric mean manganese absorption was 0.6% (range: 0.3-1.0%) and 0.6% (range: 0.3-1.1%), respectively. In conclusion, fractional manganese absorption was approximately doubled by the dephytinization of soy formula but was not influenced by an increase in the ascorbic acid content of a soy formula containing the native amount of phytic acid.”
International journal of phytoremediation · 2022 · PMID 34382480
“However, the differential response of different varieties to metal accumulation in response to foliar application of ascorbic acid is not well documented. This study was conducted to investigate the effect of exogenous application of ascorbic acid on growth response, the concentration of Ni, Cu, and Mn in three wheat varieties.”
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014 · PMID 24144963
Meta-AnalysisSystematic ReviewHuman subjects
“The lower plasma nutrient levels indicate that patients with AD have impaired systemic availability of several nutrients. This difference appears to be unrelated to the classic malnourishment that is well known to be common in AD, suggesting that compromised micronutrient status may precede protein and energy malnutrition.”
Names Manganese and Vitamin C together in an interaction, co-administration, or pharmacokinetic context.
“Lower maternal dietary antioxidant capacity, especially dORAC, was associated with a higher fetal inflammatory response, suggesting a potential role of maternal diet in modulating intrauterine inflammation in FGR. Further longitudinal studies, including assessments of trimester-specific maternal serum antioxidant levels and placental and nutritional evaluations, are warranted to explore causal relationships and potential nutritional interventions.”
Names Manganese and Vitamin C together in an interaction, co-administration, or pharmacokinetic context.
Limitations
What this evidence cannot tell you.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.
Nearby evidence
Other pairs with published research.
Pages covering Manganese or Vitamin C alongside a different substance.
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Manganese, Vitamin C, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
