NutriStack
Milk Thistle and Turmeric/Curcumin, a synergy.
Both are hepatoprotective compounds that support liver health through complementary antioxidant and anti-inflammatory mechanisms.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Milk Thistle and Turmeric/Curcumin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Both are hepatoprotective compounds that support liver health through complementary antioxidant and anti-inflammatory mechanisms.
Mechanism. Silymarin stabilizes hepatocyte cell membranes and promotes glutathione synthesis. Curcumin inhibits NF-κB-mediated hepatic inflammation and activates Nrf2 for phase II enzyme induction.
Recommendation. Effective liver support combination. Both protect hepatocytes and support detoxification.
Sources (2)
- Abenavoli L et al. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010
- Fogacci F, Grassi D, Rizzo M, Cicero AFG. Metabolic effect of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Phytotherapy Research. 2019. PMID 30632209
Stack Score
How this pair moves the number.
Effect on the composite score
If both Milk Thistle and Turmeric/Curcumin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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