Supplement × Prescription·timing-sensitive·Emerging evidence

Nystatin + Probiotics

Timing Sensitive Emerging evidence

Oral nystatin can reduce viability of yeast-containing probiotics such as Saccharomyces boulardii when taken together.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Timing Sensitive
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveEmerging evidence

What is happening. Oral nystatin can reduce viability of yeast-containing probiotics such as Saccharomyces boulardii when taken together.

Mechanism. Nystatin binds fungal cell membrane sterols and can damage susceptible yeast organisms.

Recommendation. Separate yeast probiotics from oral nystatin; bacterial probiotics are less likely to be directly affected.

Stack Score

How it moves the number.

Effect on the composite score

If both Nystatin and Probiotics are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1DailyMed. Nystatin US prescribing information. 2026.Needs sourceNo link

Check your full routine

One pair was the worked example.

Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.