What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Omeprazole + Probiotics pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Omeprazole and Probiotics, a synergy.

Q: Can I take Omeprazole and Probiotics together?

Yes. The combination of Omeprazole and Probiotics produces a measurable benefit. Omeprazole shifts the gut microbiome and roughly doubles the risk of Clostridioides difficile and small intestinal bacterial overgrowth. A 2017 Cochrane review of 39 trials found probiotics reduced C. difficile-associated diarrhea by about 60% in adults and children at increased baseline risk. Co-administration is reasonable for patients also on antibiotics or with prior C. diff.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Omeprazole shifts the gut microbiome and roughly doubles the risk of Clostridioides difficile and small intestinal bacterial overgrowth. A 2017 Cochrane review of 39 trials found probiotics reduced C. difficile-associated diarrhea by about 60% in adults and children at increased baseline risk. Co-administration is reasonable for patients also on antibiotics or with prior C. diff.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Omeprazole and Probiotics
Pair type: Synergy
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Omeprazole shifts the gut microbiome and roughly doubles the risk of Clostridioides difficile and small intestinal bacterial overgrowth. A 2017 Cochrane review of 39 trials found probiotics reduced C. difficile-associated diarrhea by about 60% in adults and children at increased baseline risk. Co-administration is reasonable for patients also on antibiotics or with prior C. diff.

Mechanism. PPI-induced hypochlorhydria removes a key barrier to enteric pathogens and permits dysbiosis with overgrowth of opportunistic bacteria. Probiotics restore a portion of the protective microbial community and competitively inhibit pathogens like C. difficile.

Recommendation. If you are on omeprazole and antibiotics, or have a history of C. diff, consider a multi-strain probiotic with documented evidence (Lactobacillus rhamnosus GG or Saccharomyces boulardii are best studied). Take the probiotic 2 hours apart from any antibiotic dose, but timing relative to omeprazole is not critical.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Omeprazole and Probiotics are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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