NutriStack
Omeprazole and Turmeric/Curcumin, a synergy.
A 2023 randomized, double-blind trial in patients with functional dyspepsia found curcumin alone, omeprazole alone, and the combination produced comparable symptom improvement over 28 days. Curcumin may serve as an adjunct or alternative for mild dyspepsia, but it is not validated for erosive esophagitis or ulcer prevention. The two are safe to take together.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Omeprazole and Turmeric/Curcumin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. A 2023 randomized, double-blind trial in patients with functional dyspepsia found curcumin alone, omeprazole alone, and the combination produced comparable symptom improvement over 28 days. Curcumin may serve as an adjunct or alternative for mild dyspepsia, but it is not validated for erosive esophagitis or ulcer prevention. The two are safe to take together.
Mechanism. Curcumin has anti-inflammatory, mucosal-protective, and modest antisecretory activity in animal and clinical studies. Its mechanism is distinct from omeprazole's proton pump inhibition, allowing additive symptom relief in functional dyspepsia.
Recommendation. If you have functional dyspepsia, discuss with your prescriber whether adding 250-500 mg of curcumin twice daily to omeprazole is appropriate. Do not replace prescribed omeprazole for severe reflux, Barrett's esophagus, or ulcer prevention without medical guidance.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Omeprazole and Turmeric/Curcumin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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