From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Probiotics and peppermint oil may both support IBS symptoms through different mechanisms.
Mechanism. Microbiome modulation plus antispasmodic smooth-muscle relaxation.
Recommendation. Reasonable to combine, but start one intervention at a time to know what helps.
Stack Score
How it moves the number.
Effect on the composite score
If both Peppermint Oil (Enteric-Coated) and Probiotics are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1NCCIH. Peppermint Oil: Usefulness and Safety. 2024.Needs sourceNo link