NutriStack
Pravastatin and Quercetin, a caution.
Quercetin increased pravastatin exposure in a human study by inhibiting OATP1B1-mediated transport. The average increase was modest, but it could matter in people with other myopathy risks or transporter variants. This is more relevant to high-dose quercetin capsules than ordinary dietary quercetin intake.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Pravastatin and Quercetin
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Quercetin increased pravastatin exposure in a human study by inhibiting OATP1B1-mediated transport. The average increase was modest, but it could matter in people with other myopathy risks or transporter variants. This is more relevant to high-dose quercetin capsules than ordinary dietary quercetin intake.
Mechanism. Quercetin competitively inhibits OATP1B1, a hepatic uptake transporter involved in pravastatin disposition. In healthy volunteers, quercetin increased pravastatin AUC and Cmax, consistent with reduced transporter-mediated clearance.
Recommendation. Use high-dose quercetin cautiously with pravastatin, especially if you have kidney disease, a history of statin muscle symptoms, or other interacting drugs. Monitor for new muscle pain or weakness after starting quercetin.
Sources (2)
- Wu LX, Guo CX, Chen WQ, Yu J, Qu Q, Chen Y, et al. Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment. Br J Clin Pharmacol. 2012;73(5):750-757. PMID 22114872
- Hirota T, Fujita Y, Ieiri I. An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins. Expert Opin Drug Metab Toxicol. 2020;16(9):809-822. PMID 32729746
Stack Score
How this pair moves the number.
Effect on the composite score
If both Pravastatin and Quercetin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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