What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Valsartan + Zinc pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Valsartan and Zinc, a caution.

Q: Can I take Valsartan and Zinc together?

Possibly, but with caution. Valsartan and Zinc have a documented caution-tier interaction. A systematic review of zinc and antihypertensive therapy reported that valsartan reduced erythrocyte and plasma zinc concentrations in treated hypertensives. The effect is smaller than with sulfhydryl-containing ACE inhibitors but still meaningful over chronic use. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

A systematic review of zinc and antihypertensive therapy reported that valsartan reduced erythrocyte and plasma zinc concentrations in treated hypertensives. The effect is smaller than with sulfhydryl-containing ACE inhibitors but still meaningful over chronic use. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Valsartan and Zinc
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. A systematic review of zinc and antihypertensive therapy reported that valsartan reduced erythrocyte and plasma zinc concentrations in treated hypertensives. The effect is smaller than with sulfhydryl-containing ACE inhibitors but still meaningful over chronic use. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.

Mechanism. Mechanism is not fully established but appears to involve increased renal zinc handling and possibly altered intracellular zinc distribution secondary to RAAS blockade. Net effect is reduced plasma and erythrocyte zinc over months of therapy.

Recommendation. If you take valsartan long term, a modest zinc supplement (15-30 mg/day) or a multivitamin containing zinc is reasonable, especially if you notice altered taste or recurrent infections. Take zinc with food to limit GI upset.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Valsartan and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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