NutriStack
Vitamin B6 and Vitamin B9, a synergy.
B6 is required for the conversion of serine to glycine, which generates 5,10-methyleneTHF needed for folate-dependent one-carbon metabolism.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin B6 and Vitamin B9
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. B6 is required for the conversion of serine to glycine, which generates 5,10-methyleneTHF needed for folate-dependent one-carbon metabolism.
Mechanism. Serine hydroxymethyltransferase (SHMT) requires PLP (B6) to transfer a methyl group from serine to THF, generating 5,10-methyleneTHF, a key folate coenzyme for nucleotide synthesis.
Recommendation. Take as part of a B-complex for optimal one-carbon metabolism and homocysteine management.
Sources (1)
- Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin B6 and Vitamin B9 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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