From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Vitamin B6 is sometimes paired with PMS support and may influence neurotransmitter and prolactin-related pathways.
Mechanism. Complementary neurotransmitter cofactor and prolactin-related effects.
Recommendation. Keep B6 below chronic high-dose ranges to avoid neuropathy.
Stack Score
How it moves the number.
Effect on the composite score
If both Vitamin B6 and Vitex (Chasteberry) are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Schellenberg R. Agnus castus PMS trial. BMJ. 2001.Needs sourceNo link