NutriStack
Symptom·Sleep·Reviewed May 30, 2026
Supplements for Difficulty falling asleep / sleep onset.
When difficulty falling asleep / sleep onset is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01MelatoninStrong85% match
Melatonin signals biological night and reliably shortens the time to fall asleep, particularly in people with delayed sleep timing or low endogenous levels.
SuggestedLow-dose immediate-release melatonin, 0.5 to 1 mg taken 30 to 60 minutes before bed - 02Magnesium GlycinateModerate72% match
Magnesium supports GABAergic relaxation and may ease the physical tension that delays sleep onset, with the clearest benefit when intake is low.
SuggestedMagnesium glycinate, 200 to 400 mg elemental magnesium before bed - 03L-TheanineLimited68% match
L-theanine increases alpha-wave activity and modulates GABA and glutamate to lower pre-sleep arousal, which may help calm a racing mind at bedtime.
SuggestedL-theanine, 100 to 200 mg about 30 minutes before bed - 04GlycineLimited62% match
Glycine lowers core body temperature, a key trigger for sleep onset, and small trials report faster sleep initiation and better next-day alertness.
SuggestedGlycine powder, 3 g in water before bed - 05Valerian RootLimited58% match
Valerian may enhance GABA signaling to produce mild sedation, though trial results are inconsistent and any effect is modest.
SuggestedStandardized valerian root extract, 300 to 600 mg taken 30 to 60 minutes before bed - 06ApigeninLimited54% match
Apigenin from chamomile binds benzodiazepine sites and may produce gentle anxiolytic and sedative effects that ease falling asleep.
SuggestedApigenin capsules (about 50 mg) or chamomile tea before bed
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