NutriStack
Symptom·Sleep·Reviewed May 30, 2026
Supplements for Wake up unrefreshed.
When wake up unrefreshed is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Magnesium GlycinateModerate78% match
Magnesium supports GABAergic tone and deep sleep architecture; deficiency disrupts sleep quality.
SuggestedMagnesium glycinate, 200 to 400 mg elemental at bedtime - 02GlycineModerate72% match
3 g glycine at bedtime lowers core body temperature, advances sleep onset, and improves morning alertness in RCTs.
SuggestedGlycine powder, 3 g 30 to 60 minutes before bed - 03AshwagandhaModerate66% match
Lowers evening cortisol and improves sleep continuity in stressed populations.
SuggestedKSM-66, 300 to 600 mg per day - 04L-TheanineLimited62% match
Theanine raises alpha brain wave activity and may improve subjective sleep quality without sedation.
SuggestedL-theanine, 100 to 200 mg at bedtime - 05Vitamin D3Limited50% match
Vitamin D deficiency is associated with poor sleep quality; restoring level may improve sleep in deficient individuals.
SuggestedVitamin D3, 2000 to 5000 IU per day adjusted by 25(OH)D
Build your stack
Every match traces to a full profile.
These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.