NutriStack
Symptom·Cardiometabolic·Reviewed May 30, 2026
Supplements for Intermittent claudication (peripheral artery leg pain on walking).
When intermittent claudication (peripheral artery leg pain on walking) is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01L-CarnitineModerate80% match
Carnitine improves oxygen-limited muscle energy metabolism, which trials link to longer pain-free and maximal walking distance.
SuggestedPropionyl-L-carnitine or L-carnitine, roughly 1 to 2 g twice daily - 02L-CitrullineLimited70% match
Citrulline raises arginine and nitric oxide to widen blood vessels and may improve blood flow to exercising leg muscles.
SuggestedL-citrulline or citrulline malate powder, 3 to 6 g daily - 03L-ArginineLimited58% match
Arginine is the direct precursor for nitric oxide synthesis and vasodilation in narrowed peripheral arteries.
SuggestedL-arginine, 2 to 3 g up to three times daily - 04Fish OilModerate52% match
Omega-3 fatty acids support endothelial function and the broader cardiovascular risk reduction that matters in peripheral artery disease.
SuggestedOmega-3 (EPA+DHA) softgels, dosed by combined EPA+DHA content - 05Pine Bark ExtractLimited50% match
Pine bark flavonoids support nitric oxide-mediated vasodilation and microcirculation in leg tissues.
SuggestedStandardized pine bark extract (Pycnogenol type), about 100 to 200 mg daily - 06Ginkgo BilobaLimited44% match
Ginkgo may modestly improve blood flow and red cell flexibility, with older trials suggesting small gains in walking distance.
SuggestedStandardized ginkgo extract (EGb 761 type), 120 to 240 mg daily
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