NutriStack
Symptom·Mood·Reviewed May 30, 2026
Supplements for Irritability.
When irritability is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Magnesium GlycinateModerate82% match
Magnesium modulates NMDA receptor activity and the stress axis, and low status is linked to heightened irritability and anxiety.
SuggestedMagnesium glycinate - 02L-TheanineModerate76% match
L-theanine increases alpha brain wave activity and may raise GABA, promoting a sense of calm without sedation.
SuggestedL-theanine - 03AshwagandhaModerate72% match
Ashwagandha is an adaptogen that may lower cortisol and perceived stress, which can reduce stress-driven irritability.
SuggestedStandardized ashwagandha root extract (for example KSM-66) - 04Vitamin B6Limited66% match
Vitamin B6 (as P5P) is a cofactor for synthesis of serotonin, GABA, and dopamine, neurotransmitters involved in mood regulation.
SuggestedPyridoxal-5-phosphate (P5P) - 05InositolLimited62% match
Inositol is a second-messenger precursor in serotonergic signaling, with some evidence for reducing anxiety and mood symptoms.
SuggestedMyo-inositol (powder) - 06Fish OilLimited58% match
Omega-3 fatty acids have anti-inflammatory and membrane effects that may modestly reduce irritability and aggression.
SuggestedHigh-EPA fish oil
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.