NutriStack
Symptom·Mood·Reviewed May 30, 2026
Supplements for Seasonal affective / winter low mood.
When seasonal affective / winter low mood is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Vitamin D3Limited85% match
Reduced winter sunlight lowers vitamin D synthesis, and because D receptors are present in mood-related brain regions, low status may be associated with seasonal low mood, though a causal role is not established.
SuggestedVitamin D3 (cholecalciferol) with a fatty meal - 02St. John's WortModerate80% match
It appears to modulate serotonin, dopamine, and norepinephrine signaling and has shown benefit for mild to moderate depression in trials.
SuggestedStandardized extract (0.3 percent hypericin) - 03Fish OilLimited68% match
Omega-3 fatty acids, particularly EPA, are incorporated into neuronal membranes and may have modest anti-inflammatory and mood-supportive effects, though results are mixed.
SuggestedHigh-EPA fish oil - 045-HTPLimited63% match
It is a direct precursor to serotonin and may support serotonergic tone relevant to mood, but human trials for seasonal mood specifically are limited.
Suggested5-HTP (Griffonia simplicifolia extract) - 05Rhodiola RoseaLimited60% match
As an adaptogen it may influence stress-axis signaling and monoamine activity, potentially reducing fatigue and low mood, though evidence is preliminary.
SuggestedStandardized extract (3 percent rosavins, 1 percent salidroside) - 06MethylfolateLimited56% match
As the active folate form it supports one-carbon metabolism and monoamine neurotransmitter synthesis, which may matter more in those with low folate or MTHFR variants.
SuggestedL-methylfolate
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