NutriStack
Symptom·Mood·Reviewed May 30, 2026
Supplements for Depression / low mood.
When depression / low mood is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Fish OilModerate84% match
EPA-predominant omega-3 support has some of the best supplement evidence for mood support.
SuggestedHigh-EPA fish oil - 02Vitamin D3Moderate72% match
Correcting low vitamin D can improve mood in people whose symptoms overlap with deficiency.
SuggestedD3 (cholecalciferol) - 03SAMeModerate71% match
SAMe participates in methylation pathways relevant to mood, though it can be activating.
SuggestedSAMe enteric-coated tablets - 04St. John's WortModerate66% match
Can support mild depressive symptoms in some people, but drug interactions are extensive and serious.
SuggestedStandardized St. John's Wort extract - 05MethylfolateModerate64% match
Active folate can support methylation and neurotransmitter synthesis, especially when folate status is low.
SuggestedMethylfolate (5-MTHF) - 06ZincLimited58% match
Zinc participates in neurotransmission and immune signaling relevant to mood.
SuggestedZinc picolinate - 07Vitamin B6Limited54% match
Supports neurotransmitter synthesis including serotonin and GABA pathways.
SuggestedP5P or pyridoxine
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.