NutriStack
Symptom·Digestive·Reviewed May 30, 2026
Supplements for Leaky gut / intestinal permeability.
When leaky gut / intestinal permeability is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01L-GlutamineLimited85% match
L-glutamine fuels enterocytes and may support tight junction integrity, which could help maintain normal intestinal permeability.
SuggestedL-glutamine powder - 02Zinc CarnosineLimited80% match
Zinc carnosine may stabilize the gastric and intestinal mucosa and support barrier repair, with some human data suggesting reduced permeability.
SuggestedZinc-L-carnosine tablets - 03ProbioticsModerate75% match
Some probiotic strains may strengthen the mucosal barrier and modulate tight junction proteins, potentially reducing permeability.
SuggestedMulti-strain probiotic (at least 10 billion CFU) - 04ColostrumLimited70% match
Bovine colostrum provides growth factors and immunoglobulins that may support mucosal integrity and reduce exercise-induced permeability in small studies.
SuggestedBovine colostrum powder - 05Saccharomyces BoulardiiLimited65% match
Saccharomyces boulardii may support the gut barrier and reduce inflammatory signaling, indirectly aiding permeability in some contexts.
SuggestedSaccharomyces boulardii CNCM I-745 capsules - 06QuercetinLimited60% match
Quercetin is a flavonoid that may stabilize mast cells and support tight junction assembly in preclinical models, with limited human permeability data.
SuggestedQuercetin phytosome (or co-formulated with bromelain) for absorption - 07Collagen PeptidesLimited55% match
Collagen peptides supply glycine and proline that may support the intestinal extracellular matrix, though direct permeability evidence is sparse.
SuggestedHydrolyzed collagen peptides powder
Build your stack
Every match traces to a full profile.
These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.