NutriStack
Symptom·Cardiometabolic·Reviewed May 30, 2026
Supplements for Low HDL cholesterol.
When low hdl cholesterol is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Vitamin B3Moderate78% match
Niacin (vitamin B3) at pharmacologic doses reduces hepatic clearance of HDL and is one of the most effective agents for raising HDL cholesterol.
SuggestedImmediate-release or extended-release niacin (vitamin B3), clinician-directed dose - 02Fish OilLimited68% match
Marine omega-3 fatty acids can modestly raise HDL and shift HDL toward larger, more functional particles in some people.
SuggestedConcentrated EPA/DHA softgels providing roughly 1 to 2 g combined daily - 03BerberineLimited58% match
Berberine improves overall lipid handling and insulin sensitivity, which can be associated with modest HDL improvement.
SuggestedBerberine HCl 500 mg, two to three times daily with meals - 04Curcumin PhytosomeLimited50% match
Curcumin may improve lipid profiles and reduce vascular inflammation, with small reported increases in HDL.
SuggestedPhytosome (phospholipid-bound) curcumin for absorption - 05L-CarnitineLimited42% match
L-carnitine supports fatty acid metabolism and has shown small HDL increases in some metabolic and dialysis populations.
SuggestedL-Carnitine tartrate, 1 to 2 g daily
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.