NutriStack
Fenugreek and Iron, timing-sensitive.
Fenugreek's high soluble fiber and polyphenol content can bind non-heme iron in the gut and reduce its absorption when taken together.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Timing Sensitive · Emerging evidence
Timing Sensitive
What is happening. Fenugreek's high soluble fiber and polyphenol content can bind non-heme iron in the gut and reduce its absorption when taken together.
Mechanism. The mucilaginous fiber and tannin-like polyphenols in fenugreek chelate and trap non-heme iron in the gastrointestinal tract, lowering the fraction available for absorption.
Recommendation. Separate fenugreek and iron supplements by at least 2 hours to preserve iron absorption.
Minimum separation. 2 hours
Sources (2)
- Srinivasan K, Fenugreek (Trigonella foenum-graecum): a review of health beneficial physiological effects, Food Reviews International, 2006
- Hurrell R, Egli I, Iron bioavailability and dietary reference values, American Journal of Clinical Nutrition, 2010. Iron bioavailability and dietary reference values. Am J Clin Nutr. 2010. PMID 20200263
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fenugreek and Iron are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.