What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Gemfibrozil + Vitamin E pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Emerging evidence

Gemfibrozil + Vitamin E

Q: Can I take Gemfibrozil and Vitamin E together?

Possibly, but with caution. Gemfibrozil and Vitamin E have a documented caution-tier interaction. High-dose vitamin E has antiplatelet/anticoagulant properties and can potentiate bleeding risk. Gemfibrozil itself can potentiate oral anticoagulants and may modestly affect bleeding parameters. Combining high-dose vitamin E with gemfibrozil, particularly in patients also taking warfarin, other anticoagulants, or antiplatelet agents, may additively increase bleeding tendency. Routine low-dose vitamin E from diet or a standard multivitamin is unlikely to be clinically significant.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

High-dose vitamin E has antiplatelet/anticoagulant properties and can potentiate bleeding risk. Gemfibrozil itself can potentiate oral anticoagulants and may modestly affect bleeding parameters. Combining high-dose vitamin E with gemfibrozil, particularly in patients also taking warfarin, other anticoagulants, or antiplatelet agents, may additively increase bleeding tendency. Routine low-dose vitamin E from diet or a standard multivitamin is unlikely to be clinically significant.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Gemfibrozil and Vitamin E

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. High-dose vitamin E has antiplatelet/anticoagulant properties and can potentiate bleeding risk. Gemfibrozil itself can potentiate oral anticoagulants and may modestly affect bleeding parameters. Combining high-dose vitamin E with gemfibrozil, particularly in patients also taking warfarin, other anticoagulants, or antiplatelet agents, may additively increase bleeding tendency. Routine low-dose vitamin E from diet or a standard multivitamin is unlikely to be clinically significant.

Mechanism. High-dose alpha-tocopherol antagonizes vitamin K-dependent clotting factor function and inhibits platelet aggregation. Gemfibrozil can displace and enhance the effect of oral anticoagulants. The combined effect is additive pharmacodynamic interference with hemostasis.

Recommendation. Keep vitamin E within ordinary dietary/multivitamin amounts; avoid high-dose vitamin E (for example, several hundred IU or more daily) with gemfibrozil unless directed by a clinician, especially if taking anticoagulant or antiplatelet medication. Watch for unusual bruising or bleeding and disclose supplement use before surgery or invasive procedures.

Stack Score

How it moves the number.

Effect on the composite score

If both Gemfibrozil and Vitamin E are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Booth SL, et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr. 2004.Needs sourceNo link
2Pastori D, et al. Vitamin E and bleeding risk: review of antiplatelet and anticoagulant effects. Nutrients. 2015.Needs sourceNo link

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