NutriStack
Grape Seed Extract and Lisinopril, a synergy.
Grape Seed Extract lowers blood pressure modestly (about 6 mm Hg systolic and 3 mm Hg diastolic in meta-analyses) through improved endothelial function and antioxidant effects. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Grape Seed Extract and Lisinopril
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Grape Seed Extract lowers blood pressure modestly (about 6 mm Hg systolic and 3 mm Hg diastolic in meta-analyses) through improved endothelial function and antioxidant effects. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.
Mechanism. Grape seed proanthocyanidins increase endothelial nitric oxide production, scavenge superoxide, and improve flow-mediated dilation. These actions complement ACE inhibition by lisinopril.
Recommendation. Grape Seed Extract 100-300 mg/day is a typical research dose; monitor home blood pressure after starting and tell your prescriber so your lisinopril dose can be reviewed.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Grape Seed Extract and Lisinopril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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