What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Iron + Itraconazole pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Emerging evidence

Iron + Itraconazole

Q: Can I take Iron and Itraconazole together?

Yes, if you separate them in time. Iron and Itraconazole have a documented timing-sensitive interaction. Oral iron salts are best absorbed in an acidic environment and are sometimes taken with antacids or co-administered with acid-reducing agents; more importantly, conditions and products that raise gastric pH impair itraconazole capsule absorption. Co-timing iron-containing multivitamin/antacid combinations with itraconazole can lower antifungal exposure.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Emerging evidence

Oral iron salts are best absorbed in an acidic environment and are sometimes taken with antacids or co-administered with acid-reducing agents; more importantly, conditions and products that raise gastric pH impair itraconazole capsule absorption. Co-timing iron-containing multivitamin/antacid combinations with itraconazole can lower antifungal exposure.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Iron and Itraconazole

Pair type

Timing Sensitive

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveEmerging evidence

What is happening. Oral iron salts are best absorbed in an acidic environment and are sometimes taken with antacids or co-administered with acid-reducing agents; more importantly, conditions and products that raise gastric pH impair itraconazole capsule absorption. Co-timing iron-containing multivitamin/antacid combinations with itraconazole can lower antifungal exposure.

Mechanism. Itraconazole capsule dissolution depends on low gastric pH; concurrent administration with buffered iron products or acid-altering co-formulations can reduce its dissolution and absorption.

Recommendation. Take itraconazole capsules with an acidic beverage and food, and separate from iron supplements (especially those formulated with calcium or buffering agents) by at least 2 hours. Monitor for signs of inadequate antifungal response.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Iron and Itraconazole are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Itraconazole (Sporanox) prescribing information. Janssen Pharmaceuticals. 2024.Needs sourceNo link
2Lange D, et al. Effect of a cola beverage on the bioavailability of itraconazole in the presence of H2 blockers. J Clin Pharmacol. 1997.Needs sourceNo link

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