What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Iron + Nystatin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Insufficient evidence

Iron + Nystatin

Q: Can I take Iron and Nystatin together?

Yes, if you separate them in time. Iron and Nystatin have a documented timing-sensitive interaction. Nystatin oral suspension is frequently dosed to coat the oral mucosa, and patients are advised to avoid food and drink shortly after dosing so the drug stays in contact with affected tissue. Oral iron supplements are gastric irritants often taken with food and acidic juices, and dosing them at the same time can wash nystatin off mucosal surfaces and prompt eating or drinking that shortens contact time. There is no systemic pharmacokinetic interaction because nystatin is not absorbed.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Insufficient evidence

Nystatin oral suspension is frequently dosed to coat the oral mucosa, and patients are advised to avoid food and drink shortly after dosing so the drug stays in contact with affected tissue. Oral iron supplements are gastric irritants often taken with food and acidic juices, and dosing them at the same time can wash nystatin off mucosal surfaces and prompt eating or drinking that shortens contact time. There is no systemic pharmacokinetic interaction because nystatin is not absorbed.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Iron and Nystatin

Pair type

Timing Sensitive

Evidence

Insufficient

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveInsufficient evidence

What is happening. Nystatin oral suspension is frequently dosed to coat the oral mucosa, and patients are advised to avoid food and drink shortly after dosing so the drug stays in contact with affected tissue. Oral iron supplements are gastric irritants often taken with food and acidic juices, and dosing them at the same time can wash nystatin off mucosal surfaces and prompt eating or drinking that shortens contact time. There is no systemic pharmacokinetic interaction because nystatin is not absorbed.

Mechanism. No systemic or chelation interaction occurs; the concern is purely local. Co-administered iron (often with food or juice) and the act of swallowing fluids physically rinse topically acting nystatin away from oral and pharyngeal Candida before it can exert its effect.

Recommendation. Take oral iron at a separate time from nystatin oral suspension, ideally separated by at least 1 to 2 hours, so the antifungal can maintain contact with the mouth and throat. After a nystatin swish-and-swallow dose, wait the directed period (about 20 to 30 minutes) before consuming iron, food, or beverages.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Iron and Nystatin are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Pappas PG, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016.Needs sourceNo link
2Lacy CF, et al. Drug Information Handbook (nystatin monograph: administration and contact-time guidance). 2017.Needs sourceNo link

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