What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Iron + Rutin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·timing-sensitive·Moderate evidence

Iron + Rutin

Q: Can I take Iron and Rutin together?

Yes, if you separate them in time. Iron and Rutin have a documented timing-sensitive interaction. Rutin is a polyphenol that can chelate non-heme iron and form poorly absorbed complexes in the gut, potentially reducing the absorption of an iron supplement if the two are taken at the same time.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Moderate evidence

Rutin is a polyphenol that can chelate non-heme iron and form poorly absorbed complexes in the gut, potentially reducing the absorption of an iron supplement if the two are taken at the same time.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Iron and Rutin

Pair type

Timing Sensitive

Evidence

Moderate

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

Timing SensitiveModerate evidence

What is happening. Rutin is a polyphenol that can chelate non-heme iron and form poorly absorbed complexes in the gut, potentially reducing the absorption of an iron supplement if the two are taken at the same time.

Mechanism. Polyphenol-iron chelation: the catechol/hydroxyl groups on the flavonoid bind ferric iron, forming insoluble complexes that lower bioavailability of dietary and supplemental non-heme iron.

Recommendation. Separate rutin from iron supplements by about 2 hours to preserve iron absorption. This is most relevant for people treating iron deficiency.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Iron and Rutin are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Hurrell RF, et al. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. British Journal of Nutrition. 1999.Needs sourceNo link

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One pair was the worked example.

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Open the interaction checker → Browse the research index