NSTK · 01.2026Independent supplement reference

Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Levofloxacin and Zinc: what the published research says

PubMed indexes 7 records that name Levofloxacin and Zinc together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Reviews & meta-analyses

Read the studies ↓ How we select sources

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Levofloxacin and Zinc. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.

The research

7 studies naming Levofloxacin and Zinc.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effective Removal of Levofloxacin from Pharmaceutical Wastewater Using Synthesized Zinc Oxid, Graphen Oxid Nanoparticles Compared with their Combination.

Scientific reports · 2020 · PMID 32246063

Comparative Study

Names both Levofloxacin and Zinc in its title.

Zinc oxide resveratrol nanoparticles ameliorate levofloxacin-induced hepatotoxicity in rat model.

BMC pharmacology & toxicology · 2025 · PMID 41454399

Animal study

“This study revealed that zinc oxide resveratrol nanoparticles modulated levofloxacin-induced hepatic damage by lowering inflammation and oxidative stress while increasing the activity of antioxidant enzymes in rat hepatic tissue.”
Zaki et al. · Authors' conclusion

Names both Levofloxacin and Zinc in its title.

Zinc oxide resveratrol nanoparticles ameliorate testicular dysfunction due to levofloxacin-induced oxidative stress in rats.

Scientific reports · 2024 · PMID 38307943

Human subjects

“Improvements were more pronounced in the co-treatment (LFX + Zn-RSV) Zinc oxide resveratrol group than in the co-treatment (LFX + Zno) Zinc oxide group. Zinc oxide resveratrol nanoparticles could be a possible solution for levofloxacin oxidative stress-induced fertility problems.”
Zaki et al. · From the abstract

Names both Levofloxacin and Zinc in its title.

Functionalized graphene oxide-zinc oxide hybrid material and its deployment for adsorptive removal of levofloxacin from aqueous media.

Environmental research · 2023 · PMID 36471557

Names both Levofloxacin and Zinc in its title.

Biosafety Photooxidation Strategy of Levofloxacin Driven by Manganese-Doped Indium Zinc Sulfide.

Chemistry, an Asian journal · 2023 · PMID 36946255

“The optimal ZIS-4% oxidation degradation rate of levofloxacin was 2.5 times higher than that of pristine ZIS, with degradation rates reaching almost 100% in 30 minutes. This study provides a novel approach to designing Mn-doped photocatalysts for antibiotic pollution control.”
Wen et al. · From the abstract

Names both Levofloxacin and Zinc in its title.

Binary Adsorption and Migration Simulation of Levofloxacin with zinc at Concentrations Simulating Wastewater on Silty Clay and The Potential Environmental Risk in Groundwater.

Chemosphere · 2023 · PMID 36419267

Names both Levofloxacin and Zinc in its title.

Transcriptomic and Functional Approaches Unveil the Role of tmRNA in Zinc Acetate Mediated Levofloxacin Sensitivity in Helicobacter pylori.

Microbiology spectrum · 2022 · PMID 36354329

Human subjects

Names both Levofloxacin and Zinc in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Levofloxacin, Zinc, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

Get NutriStack free → Read the methodology

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.