NutriStack
Levofloxacin and Zinc, timing-sensitive.
Zinc supplements bind levofloxacin in the gut and reduce its absorption by approximately 20 to 50 percent. Reduced antibiotic exposure can cause treatment failure, particularly in serious infections such as pneumonia or pyelonephritis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Levofloxacin and Zinc
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Zinc supplements bind levofloxacin in the gut and reduce its absorption by approximately 20 to 50 percent. Reduced antibiotic exposure can cause treatment failure, particularly in serious infections such as pneumonia or pyelonephritis.
Mechanism. Zn2+ chelates the 3-carboxyl and 4-oxo groups on levofloxacin, forming nonabsorbable complexes in the intestinal lumen.
Recommendation. Take levofloxacin at least 2 hours before or 2 hours after zinc supplements. Do not take in the same dose.
Minimum separation. 120
Stack Score
How this pair moves the number.
Effect on the composite score
If both Levofloxacin and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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