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Supplement × Prescription·Evidence index

Potassium and Ramipril: what the research found

PubMed indexes 8 records that name Potassium and Ramipril together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“Compared with other antihypertensive drugs, long-term use (≥ 12 months) of ACEis or ARBs showed additional benefits of preserving residual kidney function in CAPD patients. There was no significant difference on residual kidney function preservation between ARBs and ACEis.”

Zhang et al. · 2014 · Review or meta-analysis · details

“With the precautions stipulated by the protocol of the ONTARGET trial, hypokalemia and hyperkalemia were infrequent events. Nevertheless, both high and low serum potassium were associated with an increased risk of cardiovascular and renal disease.”

Heerspink et al. · 2014 · Human study · details

“We conclude that a low dose of ramipril can reduce proteinuria to the same extent as an eight-fold higher dose without significantly lowering blood pressure or increasing plasma potassium. This latter feature may be advantageous for the treatment of patients at risk for hyperkalemia who require ACE inhibitors.”

The research

8 studies naming Potassium and Ramipril.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

The effect of ramipril and telmisartan on serum potassium and its association with cardiovascular and renal events: results from the ONTARGET trial.

European journal of preventive cardiology · 2014 · PMID 24191305

Comparative StudyRandomized Controlled Trial

“With the precautions stipulated by the protocol of the ONTARGET trial, hypokalemia and hyperkalemia were infrequent events. Nevertheless, both high and low serum potassium were associated with an increased risk of cardiovascular and renal disease.”

Heerspink et al. · Authors' conclusion

Names both Potassium and Ramipril in its title.

A subdepressor low dose of ramipril lowers urinary protein excretion without increasing plasma potassium.

American journal of kidney diseases : the official journal of the National Kidney Foundation · 1999 · PMID 10070908

Clinical TrialControlled Clinical Trial13 participants

“We conclude that a low dose of ramipril can reduce proteinuria to the same extent as an eight-fold higher dose without significantly lowering blood pressure or increasing plasma potassium. This latter feature may be advantageous for the treatment of patients at risk for hyperkalemia who require ACE inhibitors.”

Keilani et al. · From the abstract

Names both Potassium and Ramipril in its title.

Ramipril decreases chlorthalidone-induced loss of magnesium and potassium in hypertensive patients.

Journal of clinical pharmacology · 1995 · PMID 8750365

Clinical TrialRandomized Controlled Trial

“At the end of the trial these changes were significant in between-group comparisons. Consistent with the previously shown amelioration by ramipril of thiazide-induced metabolic side-effects, ramipril appears to improve magnesium balance during cotreatment with chlorthalidone.”

Simunic et al. · From the abstract

Names both Potassium and Ramipril in its title.

Stability-indicating Reversed-phase Liquid Chromatographic Method for Simultaneous Determination of Losartan Potassium and Ramipril in Tablets.

Indian journal of pharmaceutical sciences · 2012 · PMID 23440900

“The method was found to be sensitive with quantification limits of 44.30 and 79.93 ng/ml for losartan potassium and ramipril. The method was successfully employed for the determination of losartan potassium and ramipril in commercially available and in-house prepared tablets.”

Kollipara et al. · From the abstract

Names both Potassium and Ramipril in its title.

RP-HPLC Method for the Determination of Losartan Potassium and Ramipril in Combined Dosage Form.

Indian journal of pharmaceutical sciences · 2010 · PMID 20582199

“The linearity range for losartan potassium and ramipril were in the range of 0.04-100 mug/ml and 0.2-300 mug/ml, respectively. The proposed method was also validated and successfully applied to the estimation of losartan potassium and ramipril in combined tablet formulations.”

Rao et al. · From the abstract

Names both Potassium and Ramipril in its title.

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for preserving residual kidney function in peritoneal dialysis patients.

The Cochrane database of systematic reviews · 2014 · PMID 24953826

Meta-AnalysisSystematic ReviewHuman subjects

“Compared with other antihypertensive drugs, long-term use (≥ 12 months) of ACEis or ARBs showed additional benefits of preserving residual kidney function in CAPD patients. There was no significant difference on residual kidney function preservation between ARBs and ACEis.”

Zhang et al. · Authors' conclusion

Names Potassium and Ramipril together in an interaction, co-administration, or pharmacokinetic context.

Renal Insufficiency and Medication in Nursing Home Residents. A Cross-Sectional Study (IMREN).

Deutsches Arzteblatt international · 2016 · PMID 26931625

Multicenter StudyHuman subjects

“Nursing home residents often suffer from renal insufficiency and should therefore have their creatinine levels measured regularly. A knowledge of the creatinine level is a prerequisite for the proper adjustment of drug doses (if necessary). A practical and compact summary of dose-adjustment recommendations for patients with renal insufficiency would be desirable but is not yet available.”

Hoffmann et al. · Authors' conclusion

Names Potassium and Ramipril together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

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