What supplements are associated with fibrocystic breast changes (lumpy, tender breast tissue)?

In the NutriStack library, the supplements most associated with fibrocystic breast changes (lumpy, tender breast tissue) are Iodine, Evening Primrose Oil, Vitamin E, Vitamin B6, Magnesium Glycinate. Each is ranked by relevance and by its own evidence rating, and links to a full profile with dosing, forms, and PubMed-cited sources.

How are supplements ranked for fibrocystic breast changes (lumpy, tender breast tissue)?

Matches are ordered by a relevance score that reflects how directly each supplement targets the symptom, then by the supplement's evidence tier. Full methodology is at https://nutristackapp.com/methodology.

Symptom·Hormone·Reviewed May 30, 2026

Supplements for Fibrocystic breast changes (lumpy, tender breast tissue).

When fibrocystic breast changes (lumpy, tender breast tissue) is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.

Matches6 supplements Strong evidence0 of 6 Last reviewedMay 30, 2026

Supplements

Ranked by relevance, top first.

Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.

01
IodineLimited
80% match
Breast tissue concentrates iodine, and molecular iodine has been studied specifically for reducing fibrocystic breast pain and nodularity.
SuggestedMolecular iodine, low supplemental doses only
02
Evening Primrose OilLimited
75% match
Evening primrose oil supplies gamma-linolenic acid thought to shift prostaglandin balance in breast tissue and is traditionally used for mastalgia.
SuggestedStandardized GLA evening primrose oil
03
Vitamin ELimited
70% match
Vitamin E is an antioxidant that may modulate prostaglandin and hormonal pathways, and small trials report modest reductions in cyclical breast pain.
SuggestedMixed tocopherols (natural d-alpha)
04
Vitamin B6Limited
55% match
Vitamin B6 is a cofactor in hormone metabolism and may ease the broader premenstrual symptom cluster that can amplify breast tenderness.
SuggestedPyridoxal-5-phosphate (P5P)
05
Magnesium GlycinateLimited
50% match
Magnesium may reduce fluid retention and the premenstrual symptom cluster, which can include breast swelling and discomfort.
SuggestedMagnesium glycinate
06
Fish OilLimited
45% match
EPA and DHA omega-3s influence prostaglandin balance and provide general anti-inflammatory support that may help breast discomfort.
SuggestedEPA/DHA triglyceride fish oil

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Supplements for Fibrocystic breast changes (lumpy, tender breast tissue).

Ranked by relevance, top first.

Related symptoms.

Every match traces to a full profile.