Symptom·Mood·Reviewed June 4, 2026
Supplements for Low mood.
When low mood is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Saffron ExtractModerate74% match
Saffron may modulate serotonin and other monoamine pathways while reducing oxidative stress.
SuggestedStandardized 28-30 mg extract - 02Crocin (Saffron Extract)Moderate70% match
Saffron constituents, including crocin and safranal, appear to inhibit reuptake of serotonin and modulate dopamine and norepinephrine, with additional antioxidant and anti-inflammatory effects on neural tissue that may support mood regulat...
SuggestedStandardized saffron extract (e.g., affron or Satiereal), typically 28 to 30 mg per day - 03Mucuna PruriensLimited30% match
Dopaminergic tone may influence anhedonia, but mucuna is not an evidence-based depression treatment.
SuggestedLow-potency standardized extract
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.