NutriStack
Symptom·Sleep·Reviewed May 30, 2026
Supplements for Non-24-hour sleep-wake rhythm (sleep timing drifts later each day).
When non-24-hour sleep-wake rhythm (sleep timing drifts later each day) is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01MelatoninModerate92% match
A fixed nightly dose at a consistent clock time provides a recurring chronobiotic signal that can entrain a free-running rhythm to a stable 24-hour cycle.
SuggestedLow-dose (0.5 mg) immediate-release at the same target bedtime every night - 02Vitamin D3Limited45% match
Supports general circadian and seasonal rhythm regulation that may otherwise be impaired alongside an unstable sleep-wake cycle.
Suggested1000 to 2000 IU daily, guided by a 25-OH-D level - 03Magnesium GlycinateModerate42% match
Calms the nervous system and supports sleep quality during the windows when sleep is attempted at the targeted entrained time.
Suggested200 to 400 mg elemental magnesium in the evening - 04L-TheanineModerate38% match
Eases pre-sleep arousal so the person can sleep during the deliberately fixed nightly window rather than drifting later.
Suggested100 to 200 mg before the target bedtime - 05Vitamin B12Limited30% match
May modestly influence circadian light sensitivity and has been explored as an adjunct in non-24-hour rhythm cases.
SuggestedMethylcobalamin 500 to 1000 mcg in the morning
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