NutriStack
Symptom·Hormone·Reviewed May 30, 2026
Supplements for PMS breast tenderness.
When pms breast tenderness is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Vitamin B6Moderate66% match
Vitamin B6 is a cofactor in neurotransmitter and hormone metabolism and may modestly ease overall premenstrual symptoms, including breast discomfort.
SuggestedVitamin B6 as pyridoxal-5-phosphate, kept at modest daily doses - 02Evening Primrose OilLimited64% match
Evening primrose oil supplies gamma-linolenic acid thought to alter prostaglandin balance in breast tissue, though controlled trials for cyclical mastalgia are mixed.
SuggestedStandardized GLA evening primrose oil softgels taken daily through the cycle - 03Magnesium GlycinateModerate62% match
Magnesium may reduce fluid retention and the broader premenstrual symptom cluster, which can include breast swelling and tenderness.
SuggestedMagnesium glycinate (bisglycinate) capsules in the luteal phase - 04Vitamin ELimited60% match
Vitamin E is an antioxidant that may modulate prostaglandin activity and has shown modest reductions in cyclical breast pain in some small trials.
SuggestedMixed tocopherols or d-alpha-tocopherol softgels with food - 05IodineLimited54% match
Iodine has been studied for fibrocystic breast discomfort on the theory that breast tissue is iodine-sensitive, but evidence is limited and dosing carries thyroid risks.
SuggestedLow-dose molecular iodine or potassium iodide, only under clinician supervision
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