From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Both can lower lipids and may affect glucose; berberine also has CYP/P-gp interaction potential.
Mechanism. Additive lipid-lowering and metabolic effects, with possible transporter/enzyme interactions.
Recommendation. Use with clinician guidance if also taking lipid or diabetes medications; monitor glucose and lipid response.
Stack Score
How it moves the number.
Effect on the composite score
If both Berberine and Red Yeast Rice are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Gerards MC et al. Red yeast rice meta-analysis. Frontiers in Pharmacology. 2022.Needs sourceNo link