NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Fish Oil and Fluoxetine: what the published research says

PubMed indexes 8 records that name Fish Oil and Fluoxetine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Fish Oil and Fluoxetine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Fish Oil and Fluoxetine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Fluoxetine may interfere with learning in fish.

Environmental toxicology and pharmacology · 2024 · PMID 38154759

Animal study

“Control fish start eating 14 times faster than the fluoxetine fish. Fluoxetine can significantly affect learning and 21-day recovery period is not enough to fully restore the original learning abilities.”

Grzesiuk et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Effects of fluoxetine on fish: What do we know and where should we focus our efforts in the future?

The Science of the total environment · 2023 · PMID 36257440

ReviewAnimal study

“We conclude that environmentally relevant concentrations of fluoxetine (e.g., from 0.00345 μg/L) produced adverse effects and often this concentration range is not addressed in conventional environmental risk assessment strategies. Its environmental persistence and ionizable properties reinforce the need for standardized testing with representative aquatic models, targeting endpoints sensitive to the specific mode of action of fluoxetine, in order to assess and rank its…”

Correia et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior.

The Science of the total environment · 2022 · PMID 34626640

ReviewHuman subjects

“This review aims to explore the current state of knowledge regarding the neurobehavioral effects of FLX and VEN on fishes. This study also discusses the potential mechanistic linkage between the neurotoxicity of ADs and behavioral dysfunction and identifies key knowledge gaps and areas for future research.”

Salahinejad et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Fins of Fury or Fainéant: Fluoxetine impacts the aggressive behavior of fighting fish (Betta splendens).

Behavioural processes · 2022 · PMID 34800605

Animal study

“However, fluoxetine was found to have profound effects on all males in the study regardless of prime type, with increases in latency for the mirror and white wall and decreases in aggressive responding to the mirror. These results support the hypothesis that fluoxetine impairs aggressive motivation and movement in Betta splendens.”

Greene et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Fluoxetine results in misleading conclusions on fish behavior.

Ecology and evolution · 2021 · PMID 34306656

“Environmental concentrations of the antidepressant influenced the time of fishes reaction and share individuals assigned as bold. Moreover, 21-day recovery lasting might be not enough to get fluoxetine effect on fishes.”

Grzesiuk et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Fluoxetine exposure disrupts food intake and energy storage in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes).

Chemosphere · 2020 · PMID 31524604

Animal study

“Taken together, these results suggest that the SSRI antidepressant FLX produces an anorectic effect in adults of C. dimerus, which could alter normal physiological function and, in consequence, have a negative impact on fish growth, reproduction, and population success.”

Dorelle et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Of fish and mirrors: Fluoxetine disrupts aggression and learning for social rewards.

Physiology & behavior · 2017 · PMID 28237550

Animal study

“In addition, our results provide support for motor inhibition of aggressive behavior as the main behavioral mechanism of action for fluoxetine. Placed within the broader context of behavioral syndromes, our results, along with others, implicate serotonergic pathways as a key biological correlate of the bold-aggressive phenotype.”

Eisenreich et al. · From the abstract

Names both Fish Oil and Fluoxetine in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Fish Oil, Fluoxetine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.