NutriStack
Fish Oil and Metoprolol, a synergy.
Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (~2-3 mmHg systolic at doses of 2-3 g/day) and lower triglycerides, complementing metoprolol's hemodynamic effects. The combination is generally beneficial in patients with hypertension or cardiovascular disease, with minimal risk at typical doses.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fish Oil and Metoprolol
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (~2-3 mmHg systolic at doses of 2-3 g/day) and lower triglycerides, complementing metoprolol's hemodynamic effects. The combination is generally beneficial in patients with hypertension or cardiovascular disease, with minimal risk at typical doses.
Mechanism. EPA and DHA enhance endothelial nitric oxide production, reduce vascular inflammation, and modulate ion channels in cardiomyocytes. These effects complement metoprolol's reduction in heart rate and cardiac workload via beta1 blockade.
Recommendation. Fish oil at 1-3 g/day combined with metoprolol is appropriate for most patients with cardiovascular risk. Monitor blood pressure when starting, and inform your prescriber if you take high doses (>3 g/day) since hemodynamic effects can become additive.
Sources (2)
- Zhang X, Ritonja JA, Zhou N, Chen BE, Li X. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022;11(11):e025071. PMID 35647665
- Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation. 1993;88(2):523-33. PMID 8339414
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fish Oil and Metoprolol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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