NutriStack
Fluconazole and Turmeric/Curcumin, a caution.
Curcumin inhibits CYP3A4 and P-glycoprotein in vitro and has altered the pharmacokinetics of CYP3A4 substrates such as amlodipine and budesonide in animal studies. Combining curcumin supplements with fluconazole adds another inhibitor to the same metabolic pathway, which can raise levels of co-prescribed drugs metabolized by CYP3A4.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fluconazole and Turmeric/Curcumin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Curcumin inhibits CYP3A4 and P-glycoprotein in vitro and has altered the pharmacokinetics of CYP3A4 substrates such as amlodipine and budesonide in animal studies. Combining curcumin supplements with fluconazole adds another inhibitor to the same metabolic pathway, which can raise levels of co-prescribed drugs metabolized by CYP3A4.
Mechanism. Curcumin is a moderate CYP3A4 and P-glycoprotein inhibitor. Combining with fluconazole compounds CYP3A4 inhibition and may slow clearance of substrate drugs.
Recommendation. Pause concentrated curcumin or turmeric extract supplements during your fluconazole course. Culinary turmeric in food is fine. Resume supplementation a few days after finishing fluconazole.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fluconazole and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.