NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Ibuprofen and Turmeric/Curcumin: what the published research says

PubMed indexes 6 records that name Ibuprofen and Turmeric/Curcumin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Ibuprofen and Turmeric/Curcumin. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Ibuprofen and Turmeric/Curcumin.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann-Pick disease type C1 mice.

Neurobiology of disease · 2014 · PMID 24631719

Animal study

“We have found that triple combination therapy has a greater neuroprotective benefit compared with single and dual therapies, increasing the time period that Npc1(-/-) mice maintained body weight and motor function and maximally delaying the onset of Purkinje cell loss. In addition, ibuprofen selectively reduced microglial activation, while curcumin had no anti-inflammatory effects, indicating differential mechanisms of action for these two therapies.”

Williams et al. · Authors' conclusion

Names both Ibuprofen and Turmeric/Curcumin in its title.

Curcumin binds to Aβ1-40 peptides and fibrils stronger than ibuprofen and naproxen.

The journal of physical chemistry. B · 2012 · PMID 22877239

“The binding free energies obtained by the molecular mechanic-Poisson-Boltzmann surface area method indicate that curcumin displays higher binding affinity than nonsteroidal anti-inflammatory drugs. Our results are in good agreement with the experiments.”

Ngo et al. · From the abstract

Names both Ibuprofen and Turmeric/Curcumin in its title.

Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat.

Immunopharmacology and immunotoxicology · 2003 · PMID 12784914

Animal study

“Interleukin-1beta increased to 2 folds on day 21 and 10 folds on day 35 which were significantly brought down by curcumin and ibuprofen. Nitric oxide level was reduced at both the time intervals, which were increased by drug treatment.”

Banerjee et al. · From the abstract

Names both Ibuprofen and Turmeric/Curcumin in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Ibuprofen, Turmeric/Curcumin, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.