NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Fish Oil and Ibuprofen: what the published research says

PubMed indexes 8 records that name Fish Oil and Ibuprofen together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Fish Oil and Ibuprofen. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Fish Oil and Ibuprofen.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Sublethal effects of diclofenac and ibuprofen, individually and in mixture, in a Neotropical fish: A multi-biomarker assessment under environmentally realistic concentrations.

Aquatic toxicology (Amsterdam, Netherlands) · 2025 · PMID 41138590

Animal study

“These findings highlight additive or synergistic toxic effects of DCF and IBU and underscore the ecological relevance of pharmaceutical mixtures. This study contributes important insights into the sublethal impacts of NSAIDs on native Neotropical fish and reinforces the need for more realistic environmental risk assessments that consider the complexity of contaminant mixtures in freshwater ecosystems.”

Vieira et al. · From the abstract

Names both Fish Oil and Ibuprofen in its title.

A computational analysis of the molecular mechanisms underlying the effects of ibuprofen and dibutyl phthalate on gene expression in fish.

Heliyon · 2024 · PMID 38845962

“Both compounds revealed a mutual molecular interaction with amino acids residues within the catalytic cavity of the docked genes. These results provide new insights into the toxic effects of ibuprofen and dibutyl phthalate on Clarias gariepinus, contributing to a better understanding of the environmental impact of these pollutants.”

Ogunwole et al. · From the abstract

Names both Fish Oil and Ibuprofen in its title.

Longer-Term Omega-3 LCPUFA More Effective Adjunct Therapy for Tuberculosis Than Ibuprofen in a C3HeB/FeJ Tuberculosis Mouse Model.

Frontiers in immunology · 2021 · PMID 33995381

Animal study

“This suggests that n-3 LCPUFAs do improve pro-resolving and anti-inflammatory properties in TB, and it may be safe and effective to co-administer as adjunct therapy with standard TB treatment, particularly longer-term. Also, our results show host benefits upon short-term co-administration of ibuprofen, but not throughout the entire TB treatment course.”

Hayford et al. · From the abstract

Names both Fish Oil and Ibuprofen in its title.

Ibuprofen degradation and energy generation in a microbial fuel cell using a bioanode fabricated from devil fish bone char.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering · 2021 · PMID 34086520

“This coincides with the COD removal and ibuprofen degradation efficiencies, which were 43.6% and 34% for BCA and 31.8% and 27% for CF. Hence, these findings confirmed that BCA in MFC could provide an alternative electrode material for ibuprofen degradation and energy generation.”

Aguilera Flores et al. · From the abstract

Names both Fish Oil and Ibuprofen in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Fish Oil, Ibuprofen, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.