NutriStack
Manganese and Zinc, timing-sensitive.
Zinc and manganese compete for shared intestinal absorption pathways, so taking high doses together can modestly reduce the absorption of one or both minerals.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Timing Sensitive · Emerging evidence
Timing Sensitive
What is happening. Zinc and manganese compete for shared intestinal absorption pathways, so taking high doses together can modestly reduce the absorption of one or both minerals.
Mechanism. Both are divalent cations that share intestinal transport routes including DMT1, so high intake of one can competitively reduce uptake of the other.
Recommendation. Separate zinc and manganese by at least 2 hours when using higher-dose supplements to minimize absorption interference.
Minimum separation. 2 hours
Stack Score
How this pair moves the number.
Effect on the composite score
If both Manganese and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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