NutriStack
Melatonin and Olanzapine, a synergy.
Melatonin has been studied as an adjunct to reduce some metabolic side effects of olanzapine, including weight and cardiometabolic changes. Randomized trials and meta-analyses suggest possible benefit, but the effects are modest and do not replace diet, activity, or metabolic monitoring. Melatonin may also add bedtime sleepiness in patients who already feel sedated on olanzapine.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Melatonin and Olanzapine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Melatonin has been studied as an adjunct to reduce some metabolic side effects of olanzapine, including weight and cardiometabolic changes. Randomized trials and meta-analyses suggest possible benefit, but the effects are modest and do not replace diet, activity, or metabolic monitoring. Melatonin may also add bedtime sleepiness in patients who already feel sedated on olanzapine.
Mechanism. Olanzapine can disrupt metabolic regulation through histamine H1, serotonin 5-HT2C, muscarinic, appetite, and insulin-sensitivity pathways. Melatonin may support circadian and metabolic signaling through MT1/MT2 receptors and antioxidant effects, but it can also add sedative pharmacodynamic effects.
Recommendation. Use melatonin with olanzapine only as an adjunct, preferably at bedtime and with your prescriber's awareness. Continue routine weight, glucose, lipid, and blood-pressure monitoring. Reduce or stop melatonin and ask for guidance if morning grogginess, falls, or worsening daytime sedation occurs.
Sources (2)
- Modabbernia A, Heidari P, Soleimani R, Sobhani A, Roshan ZA, Taslimi S, et al. Melatonin for prevention of metabolic side-effects of olanzapine in patients with first-episode schizophrenia: randomized double-blind placebo-controlled study. J Psychiatr Res. 2014;53:133-140. PMID 24607293
- Kamath A, Rather ZA. Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials. Biomed Res Int. 2018;2018:4907264. PMID 29682546
Stack Score
How this pair moves the number.
Effect on the composite score
If both Melatonin and Olanzapine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.