NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Olanzapine: what the published research says

PubMed indexes 6 records that name Alcohol and Olanzapine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Olanzapine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Alcohol and Olanzapine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Olanzapine Plus Samidorphan (ALKS 3831) in Schizophrenia and Comorbid Alcohol Use Disorder: A Phase 2, Randomized Clinical Trial.

The Journal of clinical psychiatry · 2020 · PMID 32160422

Clinical Trial, Phase IIRandomized Controlled Trial

“OLZ/SAM was not superior to olanzapine in the time to EEDS and was well tolerated in patients with schizophrenia and AUD. Further research is needed to identify effective treatments for this difficult-to-treat population.”

Brunette et al. · Authors' conclusion

Names both Alcohol and Olanzapine in its title.

The effect of olanzapine on craving and alcohol consumption.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2006 · PMID 16237394

Clinical TrialComparative StudyRandomized Controlled TrialResearch Support, N.I.H., Extramural

“After 2 weeks of treatment, participants completed a cue reactivity assessment. The results suggested that participants who were homozygous or heterozygous for the seven (or longer)-repeat allele of the DRD4 VNTR responded to olanzapine with reductions in cue-elicited craving as well as reductions in alcohol consumption over the course of the 12-week trial, whereas individuals with the shorter alleles did not respond favorably to olanzapine.”

Hutchison et al. · From the abstract

Names both Alcohol and Olanzapine in its title.

Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2003 · PMID 12888781

Clinical TrialComparative StudyRandomized Controlled Trial

“Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele of the DRD4 VNTR were classified as DRD4 L, while the other participants were classified as DRD4 S. The findings indicated that olanzapine reduces craving for alcohol at baseline for both DRD4 S and DRD4 L individuals, but only reduces craving after exposure to alcohol cues and after a priming dose of alcohol for DRD4 L individuals.”

Hutchison et al. · From the abstract

Names both Alcohol and Olanzapine in its title.

Atypical Antipsychotic Drugs in Dual Disorders: Current Evidence for Clinical Practice.

Current pharmaceutical design · 2022 · PMID 35747956

Meta-AnalysisHuman subjects

“The findings highlight the use of SGA for the treatment of psychotic symptoms in comorbidity with substance use. Future studies on people with dual diagnosis and focused on long-term evaluations are warranted and need to investigate the efficacy of newly introduced molecules, such as partial D2 agonists and longacting injectable antipsychotics.”

Martinotti et al. · Authors' conclusion

Names Alcohol and Olanzapine together in an interaction, co-administration, or pharmacokinetic context.

Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose.

Clinical toxicology (Philadelphia, Pa.) · 2021 · PMID 34424785

Systematic ReviewHuman subjects

“This systematic review found heterogenous data. The higher GRADE data was focused on a few select poisonings, while studies that addressed patients with unknown and or mixed ingestions were hampered by low rates of clinically meaningful toxicity or death. Despite these limitations, they reported a benefit of activated charcoal beyond one hour in many clinical scenarios.”

Hoegberg et al. · Authors' conclusion

Names Alcohol and Olanzapine together in an interaction, co-administration, or pharmacokinetic context.

The Characteristics and Prevalence of Agitation in an Urban County Emergency Department.

Annals of emergency medicine · 2018 · PMID 30031556

Observational StudyResearch Support, U.S. Gov't, Non-P.H.S.Human subjects

“The prevalence of agitation in the ED was 2.6%. Agitated patients frequently required restraint and sedation, with significant rates of clinical events requiring intervention.”

Miner et al. · Authors' conclusion

Names Alcohol and Olanzapine together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Olanzapine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.