NutriStack
CautionInsufficient evidence
What is happening. Melatonin may counter activating effects but can confound sleep and cognition tracking.
Mechanism. Opposing sleep-wake effects.
Recommendation. Use one CNS-active intervention at a time when possible.
Supplement × Supplement·a caution·Insufficient evidence
Melatonin + Semax
Caution
Insufficient evidence
Melatonin may counter activating effects but can confound sleep and cognition tracking.
From the database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
Stack Score
How it moves the number.
Effect on the composite score
If both Melatonin and Semax are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Sources
Sources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Dolotov OV et al. Semax and BDNF in rats. J Neurochem. 2006.Needs sourceNo link
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