Supplement × Supplement·a caution·Insufficient evidence

Melatonin + VIP (Vasoactive Intestinal Peptide)

Caution Insufficient evidence

Melatonin-related sleepiness may worsen dizziness from VIP-related hypotension.

From the database

What the row says.

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Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence

What is happening. Melatonin-related sleepiness may worsen dizziness from VIP-related hypotension.

Mechanism. Sedation plus vasodilatory lightheadedness.

Recommendation. Avoid driving or hazardous activity if dizziness occurs.

Stack Score

How it moves the number.

Effect on the composite score

If both Melatonin and VIP (Vasoactive Intestinal Peptide) are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Said SI. Vasoactive intestinal peptide in the lung. Ann N Y Acad Sci. 1991.Needs sourceNo link

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