NutriStack
Probiotics and Vitamin D3, a synergy.
Vitamin D supports the gut immune barrier. Probiotics modulate the microbiome. Together they support gut-immune axis health.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Probiotics and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Vitamin D supports the gut immune barrier. Probiotics modulate the microbiome. Together they support gut-immune axis health.
Mechanism. D3 upregulates tight junction proteins and antimicrobial peptides in the gut epithelium, creating a healthier environment for probiotic colonization and function.
Recommendation. Complementary gut health support. Vitamin D strengthens gut barrier; probiotics diversify beneficial flora.
Sources (2)
- Waterhouse M et al. Vitamin D and the gut microbiome. Nutr Rev. 2019
- Chang MC, Choo YJ. Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.. Nutrients. 2023. PMID 36771225
Stack Score
How this pair moves the number.
Effect on the composite score
If both Probiotics and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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