NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Vitamin B2 and Vitamin B6: what the published research says

PubMed indexes 4 records that name Vitamin B2 and Vitamin B6 together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Vitamin B2 and Vitamin B6. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Vitamin B2 and Vitamin B6.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms.

Food and nutrition bulletin · 2008 · PMID 18709878

ReviewHuman subjects

“This paper provides a general review on folate and vitamin B12 nutrition and metabolism and the metabolic interrelationship between these vitamins. The effects of some common polymorphisms in folate and vitamin B12 genes and the influence of vitamin B6 and riboflavin status on folate and vitamin B12 metabolism are also discussed.”

Shane · From the abstract

Names both Vitamin B2 and Vitamin B6 in its title.

A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022 · PMID 33901663

Meta-AnalysisHuman subjects

“Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein.”

Papadimitriou et al. · Authors' conclusion

Names Vitamin B2 and Vitamin B6 together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Vitamin B2, Vitamin B6, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.