NutriStack
Symptom·Hormone·Reviewed May 30, 2026
Supplements for Estrogen dominance support.
When estrogen dominance support is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01DIMLimited84% match
Diindolylmethane may shift estrogen metabolism toward the 2-hydroxy pathway, which is hypothesized to favor a more balanced metabolite profile.
SuggestedMicroencapsulated diindolylmethane (DIM) - 02SulforaphaneLimited78% match
Activates Nrf2 and may upregulate phase II detoxification enzymes that participate in estrogen conjugation and clearance.
SuggestedBroccoli seed extract with active myrosinase (glucoraphanin) - 03Milk ThistleLimited70% match
Silymarin may support hepatocyte antioxidant defenses, which could aid the liver's role in metabolizing and clearing estrogens.
SuggestedStandardized milk thistle extract (about 80 percent silymarin) - 04Vitamin B6Limited64% match
Serves as a cofactor in steroid hormone metabolism and may modestly ease luteal-phase symptoms tied to estrogen and progesterone balance.
SuggestedPyridoxal 5-phosphate (P5P) - 05Magnesium GlycinateLimited60% match
Acts as a cofactor for COMT and other methylation enzymes thought to participate in catechol estrogen clearance.
SuggestedMagnesium glycinate - 06CalciumModerate56% match
Higher dietary calcium intake has been associated with milder premenstrual symptoms, providing supportive rather than direct estrogen-clearance benefit.
SuggestedCalcium citrate
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