NutriStack
Symptom·Hormone·Reviewed May 30, 2026
Supplements for Painful periods / dysmenorrhea.
When painful periods / dysmenorrhea is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Magnesium GlycinateModerate84% match
Magnesium helps relax uterine smooth muscle and may dampen prostaglandin-driven cramping, a key pain mechanism in primary dysmenorrhea.
SuggestedMagnesium glycinate capsules, taken daily through the cycle - 02Ginger ExtractModerate82% match
Ginger inhibits prostaglandin and leukotriene synthesis, which has lowered menstrual pain comparably to NSAIDs in small trials.
SuggestedStandardized ginger root extract capsules - 03Fish OilModerate76% match
EPA and DHA may shift prostaglandin balance toward less inflammatory mediators, which could reduce cramp severity over repeated cycles.
SuggestedHigh-EPA triglyceride fish oil - 04Vitamin B6Limited68% match
Vitamin B6 is a cofactor in neurotransmitter synthesis and is commonly used for PMS-linked cramping and mood symptoms, though dysmenorrhea evidence is preliminary.
SuggestedPyridoxal-5-phosphate (P5P) capsules - 05Turmeric/CurcuminLimited64% match
Curcumin has anti-inflammatory activity that may modestly reduce menstrual and premenstrual symptoms in early studies.
SuggestedCurcumin with piperine or a high-absorption (phytosome) form - 06Evening Primrose OilLimited58% match
Evening primrose oil supplies gamma-linolenic acid, a precursor that may influence prostaglandin pathways tied to cramping and breast tenderness.
SuggestedCold-pressed evening primrose oil softgels - 07Vitamin D3Limited56% match
Adequate vitamin D status is associated with lower prostaglandin activity, and correcting deficiency may ease pain in some people.
SuggestedD3 (cholecalciferol) drops or softgels
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