NutriStack
Symptom·Hormone·Reviewed May 30, 2026
Supplements for Perimenopause symptoms.
When perimenopause symptoms is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Black CohoshModerate86% match
May act on serotonergic and possibly central thermoregulatory pathways rather than as a direct estrogen, which could modestly ease vasomotor symptoms such as hot flashes.
SuggestedStandardized Cimicifuga racemosa root extract (triterpene glycosides) - 02Magnesium GlycinateModerate80% match
May support neuromuscular relaxation and sleep regulation, which could help the sleep disruption, irritability, and muscle tension common in perimenopause.
SuggestedMagnesium glycinate - 03Vitamin D3Moderate74% match
Supports calcium absorption and bone metabolism, which becomes increasingly relevant as declining estrogen accelerates bone turnover.
SuggestedVitamin D3 (cholecalciferol) - 04Maca RootLimited66% match
A non-hormonal root that may support energy, mood, and libido through poorly characterized neuroendocrine pathways rather than direct estrogen activity.
SuggestedGelatinized Maca root powder - 05CalciumModerate60% match
Provides substrate for bone mineralization to help offset the increased bone resorption that accompanies falling estrogen levels.
SuggestedCalcium citrate - 06Evening Primrose OilLimited56% match
Provides gamma-linolenic acid feeding prostaglandin pathways that may modestly help breast tenderness, though controlled hot-flash data are weak.
SuggestedCold-pressed evening primrose oil (standardized GLA)
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