NutriStack
Symptom·Hormone·Reviewed May 30, 2026
Supplements for PMDD (premenstrual dysphoric disorder).
When pmdd (premenstrual dysphoric disorder) is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01CalciumModerate78% match
Daily calcium has reduced luteal-phase mood, irritability, and physical symptoms in randomized trials of severe premenstrual symptoms.
SuggestedCalcium carbonate or citrate, around 1000 to 1200 mg daily in divided doses - 02Vitamin B6Moderate70% match
Vitamin B6 is a cofactor for serotonin and GABA synthesis and modestly improved premenstrual mood symptoms across several trials.
SuggestedPyridoxal-5-phosphate (P5P), kept under 100 mg daily - 03Magnesium GlycinateLimited64% match
Magnesium supports GABAergic tone and may ease luteal-phase mood swings, irritability, and fluid retention, especially alongside vitamin B6.
SuggestedMagnesium glycinate, around 200 to 300 mg elemental in the evening - 04InositolLimited60% match
Myo-inositol acts on serotonin receptor signaling and reduced premenstrual dysphoric symptoms in small controlled studies.
SuggestedMyo-inositol powder, around 2 to 4 g daily - 05Fish OilLimited55% match
Omega-3 fatty acids have anti-inflammatory and mood-supportive effects that may blunt premenstrual depressive symptoms.
SuggestedEPA-forward fish oil providing about 1 to 2 g combined EPA and DHA daily - 065-HTPLimited48% match
5-HTP is a direct serotonin precursor and may help the low-serotonin component of premenstrual mood symptoms.
Suggested5-HTP 50 to 100 mg in the evening, often used during the luteal phase
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